Natroceutics Berberine ComplexOne of the most powerful natural compounds, berberine is a potent AMPK (adenosine monophosphate protein kinase) activator in the body known as the metabolic master switch to regulate blood sugar levels, blood pressure, healthy cholesterol levels and body composition. AMPK can be activated naturally through calorie restriction and exercise. The primary mode of action for metformin, a major pharmaceutical drug for diabetes, is the activation of AMPK.